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1

Targeting S-adenosylmethionine biosynthesis with a novel allosteric inhibitor of Mat2A

Quinlan, Casey L, Kaiser, Stephen E, Bolaños, Ben, Nowlin, Dawn, Grantner, Rita, Karlicek-Bryant, Shannon, Feng, Jun Li, Jenkinson, Stephen, Freeman-Cook, Kevin, Dann, Stephen G, Wang, Xiaoli, Wells,

Journal:

Nature Chemical Biology

Year:

2017

Language:

english

File:

PDF, 2.09 MB

english, 2017

2

Lipophilic efficiency: the most important efficiency metric in medicinal chemistry

Freeman-Cook, Kevin D, Hoffman, Robert L, Johnson, Ted W

Journal:

Future Medicinal Chemistry

Year:

2013

Language:

english

File:

PDF, 4.42 MB

english, 2013

3

Designing glucokinase activators with reduced hypoglycemia risk: discovery of N,N-dimethyl-5-(2-methyl-6-((5-methylpyrazin-2-yl)-carbamoyl)benzofuran-4-yloxy)pyrimidine-2-carboxamide as a clinical candidate for the treatment of type 2 diabetes mellitus

Pfefferkorn, Jeffrey A., Guzman-Perez, Angel, Oates, Peter J., Litchfield, John, Aspnes, Gary, Basak, Arindrajit, Benbow, John, Berliner, Martin A., Bian, Jianwei, Choi, Chulho, Freeman-Cook, Kevin, C

Journal:

Year:

2011

Language:

english

File:

PDF, 652 KB

english, 2011

4

ChemInform Abstract: A Symmetry-Based Formal Synthesis of Zaragozic Acid A.

Kevin D. Freeman-Cook, Randall L. Halcomb

Journal:

Year:

2001

File:

PDF, 33 KB

2001

5

Maximizing Lipophilic Efficiency: The Use of Free-Wilson Analysis in the Design of Inhibitors of Acetyl-CoA Carboxylase

Freeman-Cook, Kevin D., Amor, Paul, Bader, Scott, Buzon, Leanne M., Coffey, Steven B., Corbett, Jeffrey W., Dirico, Kenneth J., Doran, Shawn D., Elliott, Richard L., Esler, William

Journal:

Journal of Medicinal Chemistry

Year:

2012

Language:

english

File:

PDF, 380 KB

english, 2012

6

A Symmetry-Based Formal Synthesis of Zaragozic Acid A

Freeman-Cook, Kevin D., Halcomb, Randall L.

Journal:

Journal of Organic Chemistry

Year:

2000

Language:

english

File:

PDF, 107 KB

english, 2000

7

Potent, selective pyrimidinetrione-based inhibitors of MMP-13

Lawrence A. Reiter, Kevin D. Freeman-Cook, Christopher S. Jones, Gary J. Martinelli, Amy S. Antipas, Martin A. Berliner, Kaushik Datta, James T. Downs, James D. Eskra, Michael D. Forman, Elaine M. Gre

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2006

Language:

english

File:

PDF, 208 KB

english, 2006

8

Identification of an Inhibitor of the MurC Enzyme, Which Catalyzes an Essential Step in the Peptidoglycan Precursor Synthesis Pathway

Zawadzke, Laura E., Norcia, Michael, Desbonnet, Charlene R., Wang, Hong, Freeman-Cook, Kevin, Dougherty, Thomas J.

Journal:

Assay and Drug Development Technologies

Year:

2008

Language:

english

File:

PDF, 928 KB

english, 2008

9

Corrections to Design of Selective, ATP-Competitive Inhibitors of Akt

Freeman-Cook, Kevin D., Autry, Christopher, Borzillo, Gary, Gordon, Deborah, Barbacci-Tobin, Elsa, Bernardo, Vincent, Briere, David, Clark, Tracey, Corbett, Matthew, Jakubczak, John, Kakar, Shefali, K

Journal:

Journal of Medicinal Chemistry

Year:

2010

Language:

english

File:

PDF, 546 KB

english, 2010

10

Discovery of small molecule isozyme non-specific inhibitors of mammalian acetyl-CoA carboxylase 1 and 2

Jeffrey W. Corbett, Kevin D. Freeman-Cook, Richard Elliott, Felix Vajdos, Francis Rajamohan, Darcy Kohls, Eric Marr, Hailong Zhang, Liang Tong, Meihua Tu, Sharad Murdande, Shawn D. Doran, Janet A. Hou

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2010

Language:

english

File:

PDF, 987 KB

english, 2010

11

Synthesis of bicyclic ketals related to zaragozic acid by a novel photoannulation

Kevin D Freeman-Cook, Randall L Halcomb

Journal:

Tetrahedron Letters

Year:

1996

Language:

english

File:

PDF, 230 KB

english, 1996

12

Synthesis of Unprotected Carboxy Indazoles via Pd-Catalyzed Carbonylation

Wainwright, Philip, Perni, Remedios, Vickers, Clare, Coffey, Steven B., Buzon, Leanne, DiRico, Kenneth, Nelson, Kendra L., Zhao, Zhengrong, Limberakis, Chris, Freeman-Cook, Kevin D., Corbett, Jeffrey

Journal:

Synthetic Communications

Year:

2012

Language:

english

File:

PDF, 273 KB

english, 2012

13

Identification of Tetrahydropyrido[4,3- d ]pyrimidine Amides as a New Class of Orally Bioavailable TGR5 Agonists

Piotrowski, David W., Futatsugi, Kentaro, Warmus, Joseph S., Orr, Suvi T. M., Freeman-Cook, Kevin D., Londregan, Allyn T., Wei, Liuqing, Jennings, Sandra M., Herr, Michael, Coffey, Steven B., Jiao, We

Journal:

ACS Medicinal Chemistry Letters

Year:

2013

Language:

english

File:

PDF, 370 KB

english, 2013

14

Synthesis and biological evaluation of novel hygromycin A antibacterial agents

Michael S. Visser, Kevin D. Freeman-Cook, Steven J. Brickner, Katherine E. Brighty, Phuong T. Le, Sarah K. Wade, Rhonda Monahan, Gary J. Martinelli, Kyle T. Blair, Dianna E. Moore

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2010

Language:

english

File:

PDF, 1.34 MB

english, 2010

15

A symmetry-based approach to zaragozic acid: Synthesis and end-differentiation of an advanced intermediate

Kevin D. Freeman-Cook, Randall L. Halcomb

Journal:

Tetrahedron Letters

Year:

1998

Language:

english

File:

PDF, 278 KB

english, 1998

16

Potent, selective spiropyrrolidine pyrimidinetrione inhibitors of MMP-13

Kevin D. Freeman-Cook, Lawrence A. Reiter, Mark C. Noe, Amy S. Antipas, Dennis E. Danley, Kaushik Datta, James T. Downs, Shane Eisenbeis, James D. Eskra, David J. Garmene, Elaine M. Greer, Richard J.

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2007

Language:

english

File:

PDF, 167 KB

english, 2007

17

Design of Selective, ATP-Competitive Inhibitors of Akt

Freeman-Cook, Kevin D., Autry, Christopher, Borzillo, Gary, Gordon, Deborah, Barbacci-Tobin, Elsa, Bernardo, Vincent, Briere, David, Clark, Tracey, Corbett, Matthew, Jakubczak, John, Kakar, Shefali, K

Journal:

Journal of Medicinal Chemistry

Year:

2010

Language:

english

File:

PDF, 2.43 MB

english, 2010

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